Fusobacterium nucleatum as a two-hit amplifier in colorectal cancer pathogenesis: intersection of local and systemic mechanisms via the gut-kidney axis.

Key Points

• This research aims to explore how Fusobacterium nucleatum contributes to the progression of colorectal cancer through local and systemic mechanisms.
• Examined the role of Fusobacterium nucleatum in collaboration with genetic lesions influencing colorectal cancer development.
• Investigated the interactions between local gut microbiota and systemic pathways through the gut-kidney axis.
• Fusobacterium nucleatum accelerates disease progression when combined with particular genetic changes.
• Findings support the development of innovative diagnostics and therapies, such as phage therapy and vaccines, to improve outcomes for colorectal cancer patients.