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May 1, 2026Open Access

Fusobacterium nucleatum as a two-hit amplifier in colorectal cancer pathogenesis: intersection of local and systemic mechanisms via the gut-kidney axis.

Hidehisa Shimizu

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Key Points

This research aims to explore how Fusobacterium nucleatum contributes to the progression of colorectal cancer through local and systemic mechanisms.
Examined the role of Fusobacterium nucleatum in collaboration with genetic lesions influencing colorectal cancer development.
Investigated the interactions between local gut microbiota and systemic pathways through the gut-kidney axis.
Fusobacterium nucleatum accelerates disease progression when combined with particular genetic changes.
Findings support the development of innovative diagnostics and therapies, such as phage therapy and vaccines, to improve outcomes for colorectal cancer patients.

Implication

Investigates Fusobacterium nucleatum's impact on colorectal cancer progression, suggesting new therapies.

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Cite This Study

Hidehisa Shimizu (2026) studied this question.

synapsesocial.com/papers/69fada7f03f892aec9b1e4ec https://doi.org/10.20407/fmj.2025-042

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Keep reading

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