What question did this study set out to answer?

To evaluate the efficacy of Coreopsis tinctoria-loaded gels in enhancing skin retention and repair mechanisms.

May 7, 2026Pharmaceutical Development and Technology0 citations

Coreopsis tinctoria -Loaded Gels for Dermal Delivery: Development, Optimization, Retention Capacity, and Skin Photoaging Repair

JDJuan DuShandong University of Technology KTKeke TaoShandong University of Traditional Chinese Medicine XCXinmei ChenShandong University of Traditional Chinese Medicine

Key Points

To evaluate the efficacy of Coreopsis tinctoria-loaded gels in enhancing skin retention and repair mechanisms.
Developed and optimized Coreopsis tinctoria-loaded gels (CTGs) for dermal delivery.
Compared CTGs with liquid formulations in terms of skin retention and adhesion.
Assessed antioxidant activity using markers like SOD, hydroxyproline, MDA, and tyrosinase.
CTGs showed significantly longer skin retention time compared to liquid formulations.
CTGs improved skin adhesion within 8 hours.
CTGs reduced UVB-induced dermal damage and increased SOD activity and hydroxyproline content.

Abstract

drug release from CTGs followed the Korsmeyer-Peppas model. Compared with the liquid formulation, CTGs significantly prolonged skin retention time and improved skin adhesion within 8 h. CTGs attenuated UVB-induced dermal damage, increased SOD activity and hydroxyproline (Hyp) content, and reduced MDA content and tyrosinase (Tyr) activity, indicating strong antioxidant and tyrosinase inhibitory activity. CTGs represent a promising dermal delivery strategy for ameliorating skin photoaging and abnormal pigmentation.

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Cite This Study

Du et al. (Tue,) studied this question.

synapsesocial.com/papers/69fbe3aa164b5133a91a2f30 https://doi.org/https://doi.org/10.1080/10837450.2026.2669970

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