Scaffold Protein PDLIM5 Regulates TRPC1 Calcium Channel Mediated Store‐Operated Calcium Entry in Mouse Myoblasts

Key Points

• This research aims to understand how PDLIM5 influences calcium entry through TRPC1 in myoblasts.
• Utilized C2C12 mouse myoblasts to investigate calcium entry mechanisms.
• Assessed myogenic differentiation in relation to PDLIM5 and TRPC1 activities.
• TRPC1 was found to mediate store-operated calcium entry in C2C12 cells.
• PDLIM5 positively regulates the expression and function of TRPC1, contributing to myoblast differentiation.