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May 1, 2026Journal of Cellular Physiology

Scaffold Protein PDLIM5 Regulates TRPC1 Calcium Channel Mediated Store‐Operated Calcium Entry in Mouse Myoblasts

Mingyi Dong Tomoaki Niimi Andrés D. Maturana

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Key Points

This research aims to understand how PDLIM5 influences calcium entry through TRPC1 in myoblasts.
Utilized C2C12 mouse myoblasts to investigate calcium entry mechanisms.
Assessed myogenic differentiation in relation to PDLIM5 and TRPC1 activities.
TRPC1 was found to mediate store-operated calcium entry in C2C12 cells.
PDLIM5 positively regulates the expression and function of TRPC1, contributing to myoblast differentiation.

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Implication

Research demonstrates TRPC1 regulates calcium entry in C2C12 cells, suggesting a crucial role for PDLIM5 in muscle development.

Abstract

entry in C2C12 cells, thereby regulating myogenic differentiation and contributing to skeletal muscle formation and development.

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Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/69fbefef164b5133a91a4063 https://doi.org/10.1002/jcp.70173

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