ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8+ T cell immunity

Key Points

• This research aims to explore the role of ERα in dendritic cells and its effect on antigen cross-presentation and T cell immunity.
• Investigated the function of ERα in dendritic cells
• Analyzed phagosome integrity involved in antigen processing
• Evaluated CD8+ T cell responses to ERα blockade
• ERα blockade improves antigen cross-presentation in dendritic cells
• Enhanced CD8+ T cell immunity observed
• Identified phagosome integrity as a critical checkpoint for antigen processing