Short-term lithium treatment modulates excitation/inhibition balance in resting-state electroencephalography (EEG) among survivors of medically severe suicide attempts.

Key Points

• This research aims to examine the effects of short-term lithium treatment on brain activity and its potential as a biomarker in individuals at high risk of suicide.
• Analysis of resting-state electroencephalography (EEG) before and after lithium treatment in individuals with a history of severe suicide attempts.
• Focus on frequency band changes, including gamma and aperiodic slope.
• Utilization of statistical methods to assess drug effects.
• Significant increase in gamma power (p < .001), indicating a restored excitation/inhibition balance.
• Alteration in aperiodic slope consistent with enhanced neural synchrony.
• Findings suggest potential EEG biomarkers for lithium's effects in high suicide risk populations.