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This research aims to examine the effects of short-term lithium treatment on brain activity and its potential as a biomarker in individuals at high risk of suicide.

May 9, 2026Experimental and Clinical Psychopharmacology0 citations

Short-term lithium treatment modulates excitation/inhibition balance in resting-state electroencephalography (EEG) among survivors of medically severe suicide attempts.

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NMNicholas Murphy YTYnhi T. Thomas IMIoana Murgulet

Key Points

This research aims to examine the effects of short-term lithium treatment on brain activity and its potential as a biomarker in individuals at high risk of suicide.
Analysis of resting-state electroencephalography (EEG) before and after lithium treatment in individuals with a history of severe suicide attempts.
Focus on frequency band changes, including gamma and aperiodic slope.
Utilization of statistical methods to assess drug effects.
Significant increase in gamma power (p < .001), indicating a restored excitation/inhibition balance.
Alteration in aperiodic slope consistent with enhanced neural synchrony.
Findings suggest potential EEG biomarkers for lithium's effects in high suicide risk populations.

Abstract

< .001). Other frequency band changes (beta, alpha) showed drug effects in analysis of variance but lacked consistent post hoc support. The increase in gamma power and alteration in aperiodic slope suggest engagement of cortical network mechanisms consistent with restored excitation/inhibition balance and enhanced neural synchrony. These preliminary neurophysiological findings support the possibility that electroencephalography-based measures could serve as objective biomarkers for lithium's neural effects in individuals at high suicide risk and warrant further large-scale studies integrating behavior and neurochemistry. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

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Murphy et al. (2026) studied this question.

synapsesocial.com/papers/69fed03cb9154b0b82877451 https://doi.org/10.1037/pha0000857

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May 9, 2026Experimental and Clinical Psychopharmacology0 citations

Short-term lithium treatment modulates excitation/inhibition balance in resting-state electroencephalography (EEG) among survivors of medically severe suicide attempts.

View Full Paper

NMNicholas Murphy YTYnhi T. Thomas IMIoana Murgulet

Key Points

This research aims to examine the effects of short-term lithium treatment on brain activity and its potential as a biomarker in individuals at high risk of suicide.
Analysis of resting-state electroencephalography (EEG) before and after lithium treatment in individuals with a history of severe suicide attempts.
Focus on frequency band changes, including gamma and aperiodic slope.
Utilization of statistical methods to assess drug effects.
Significant increase in gamma power (p < .001), indicating a restored excitation/inhibition balance.
Alteration in aperiodic slope consistent with enhanced neural synchrony.
Findings suggest potential EEG biomarkers for lithium's effects in high suicide risk populations.

Abstract

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Cite This Study

Murphy et al. (2026) studied this question.

synapsesocial.com/papers/69fed03cb9154b0b82877451 https://doi.org/10.1037/pha0000857

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