Pharmacokinetic assessment of JUUL2 18 mg/mL electronic nicotine delivery system in four flavors relative to cigarettes and a 5% (58 mg/mL) nicotine pod-based electronic nicotine delivery system among adult dual users.

use; and (c) nicotine exposure did not significantly vary between tobacco- and menthol-flavored JUUL2 products. These results indicate that (a) JUUL2 18 mg/mL products expose users to significantly lower levels of nicotine than cigarettes, suggesting lower abuse liability; (b) abuse liability of JUUL2 18 mg/mL products is within the range of NJOY Ace 5%, an Food and Drug Administration-authorized pod-based ENDS; and (c) flavor did not significantly affect nicotine delivery from JUUL2 18 mg/mL products. (PsycInfo Database Record (c) 2026 APA, all rights reserved).