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August 13, 2026Experimental and Clinical Psychopharmacology

The impact of fluoxetine on the aversive effects of lysergic acid diethylamide.

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Implication

Randomized trial examines fluoxetine's impact on aversive effects of LSD in male rats, suggesting potential implications.

Key Points

  • This research aims to determine how fluoxetine affects the aversive effects of LSD in a behavioral model.
  • Tested fluoxetine (10 mg/kg) in male Sprague-Dawley rats prior to LSD exposure.
  • Conducted taste avoidance conditioning with saccharin and LSD over six trials.
  • Evaluated consumption patterns post-treatment to assess the effects of fluoxetine on taste avoidance.
  • Fluoxetine did not significantly affect overall LSD-induced consumption.
  • A subset of subjects in the fluoxetine-LSD group showed lower consumption than the corresponding vehicle group.
  • Indicates a potential attenuating effect of fluoxetine on aversive responses to LSD.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d75f62b0e0cff3f63efdbhttps://doi.org/10.1037/pha0000876
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Effects of Acute and Chronic Fluoxetine on Psychedelic-Induced Behavior in Mice: Implications for Clinical Trials2026
  2. 2The Effect of Acute and Chronic Administration of Fluoxetine on R−(−)− DOI Induced Head Twitch Response in Swiss-Webster Mice2024
  3. 3Effects of discontinuation of serotonergic antidepressants prior to psilocybin therapy versus escitalopram for major depression2024 · 29 citations
  4. 4327. 5-HT2B RECEPTORS MODULATE THE ANTIDEPRESSANT-LIKE RESPONSE OF THE PSYCHEDELIC LSD IN RAT BUT NOT IN MICE2025
  5. 5Contribution of the Serotonin 5‐ HT 2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress2026