5-Ht2b Receptors Modulate the Antidepressant-Like Response of the Psychedelic LSD in Rat but Not in Mice

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Behavioral analysis shows LSD increases head twitch responses in rats but not in mice, suggesting 5-HT2B's role in antidepressant effects.

LSD increased the head twitch response in rats, indicating its serotonergic effects are modulated by 5-HT2B receptors.
The interaction of LSD and RS 127445 demonstrated a significant antidepressant response reduction in rats, with no effect in mice.
Assessment involved behavioral paradigms, highlighting the differential effects of LSD's action in rats and mice.
Results indicate that 5-HT2B receptors may be crucial for understanding LSD's long-lasting antidepressant effects in rat models.

Bouloufa et al. (2025) studied this question.

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Behavioral analysis shows LSD increases head twitch responses in rats but not in mice, suggesting 5-HT2B's role in antidepressant effects.

LSD increased the head twitch response in rats, indicating its serotonergic effects are modulated by 5-HT2B receptors.
The interaction of LSD and RS 127445 demonstrated a significant antidepressant response reduction in rats, with no effect in mice.
Assessment involved behavioral paradigms, highlighting the differential effects of LSD's action in rats and mice.
Results indicate that 5-HT2B receptors may be crucial for understanding LSD's long-lasting antidepressant effects in rat models.

Bouloufa et al. (2025) studied this question.

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