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June 16, 2024Open Access

Increased 5-HT2Areceptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics

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Authors

AIAurelija IppolitoSVSridhar R. VasudevanSHShaun Hurley

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Cite This Study

Ippolito et al. (2024) studied this question.

synapsesocial.com/papers/68e64883b6db6435875d9cd7https://doi.org/10.1101/2024.06.13.594677
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathway-selective signaling of serotonergic psychedelics at 5-HT receptors: Implications for psychoactivity, safety, and therapeutic potential2026 · 4 citations
  2. 2Biased Signaling in Psychedelic Action.2025
  3. 35-HT2A receptor and psychedelics: a trip through the mechanisms of action and therapeutic potential in mental disorders2026
  4. 4A dual-receptor model of serotonergic psychedelics2024 · 3 citations
  5. 5α2-Adrenergic receptor modulates 5-HT2A-mediated behavioral effects of MDMA and psilocybin in mice2026