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Synthesize current evidence on the neuroanatomy, signaling cascades, and therapeutic potential of serotonin 5-HT2A receptors targeted by psychedelic compounds.

September 17, 2026Translational PsychiatryOpen Access

5-HT2A receptor and psychedelics: a trip through the mechanisms of action and therapeutic potential in mental disorders

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Authors

MAMuhammad Asim JSJulia A. Galiza Soares JTJason Tucciarone

Discussion

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Overview

Review uncovers how psychedelic activation of serotonin 5-HT2A receptors drives neuroplasticity in mental disorders, highlighting therapeutic potential for neuropsychiatric conditions.

Key Points

Synthesize current evidence on the neuroanatomy, signaling cascades, and therapeutic potential of serotonin 5-HT2A receptors targeted by psychedelic compounds.
Narrative synthesis of preclinical and clinical studies evaluating 5-HT2A receptor neuroanatomical distribution and downstream signaling pathways.
Review of mechanistic models linking receptor agonism to circuit-level neurotransmission modulation and neuroplasticity in psychiatric illness.
Psychedelics act as agonists at the 5-HT2A receptor, driving circuit-specific modulation of neurotransmission and enhancing structural and functional neuroplasticity.
Activation of 5-HT2A receptor pathways induces robust alterations in mood, cognition, and perception, presenting a viable target for psychiatric disorders.
Delineating the precise neural circuits that translate 5-HT2A receptor stimulation into discrete behavioral outcomes remains an unresolved challenge.

Cite This Study

Asim et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6635f706d05830e4c32 https://doi.org/10.1038/s41398-026-04455-y

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September 17, 2026Translational PsychiatryOpen Access

5-HT2A receptor and psychedelics: a trip through the mechanisms of action and therapeutic potential in mental disorders

View Full Paper

Ask AI

Bookmark

Authors

MAMuhammad Asim JSJulia A. Galiza Soares JTJason Tucciarone

Discussion

Member takes

Overview

Review uncovers how psychedelic activation of serotonin 5-HT2A receptors drives neuroplasticity in mental disorders, highlighting therapeutic potential for neuropsychiatric conditions.

Key Points

Synthesize current evidence on the neuroanatomy, signaling cascades, and therapeutic potential of serotonin 5-HT2A receptors targeted by psychedelic compounds.
Narrative synthesis of preclinical and clinical studies evaluating 5-HT2A receptor neuroanatomical distribution and downstream signaling pathways.
Review of mechanistic models linking receptor agonism to circuit-level neurotransmission modulation and neuroplasticity in psychiatric illness.
Psychedelics act as agonists at the 5-HT2A receptor, driving circuit-specific modulation of neurotransmission and enhancing structural and functional neuroplasticity.
Activation of 5-HT2A receptor pathways induces robust alterations in mood, cognition, and perception, presenting a viable target for psychiatric disorders.
Delineating the precise neural circuits that translate 5-HT2A receptor stimulation into discrete behavioral outcomes remains an unresolved challenge.

Cite This Study

Asim et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6635f706d05830e4c32 https://doi.org/10.1038/s41398-026-04455-y

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