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July 26, 2025Acta Neuropsychiatrica

Narrating the psychoneuroimmunomodulatory properties of serotonin 5-HT2A receptor psychedelics from a transdiagnostic perspective

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Authors

GTGuillaume ThueryCSClare SheridanPIPatricia Iusan

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Overview

Narrative review highlights the immunomodulatory effects of 5-HT2A psychedelics on the immune and nervous systems, suggesting therapeutic potential.

Key Points

  • Psychedelics acting on the 5-HT2A receptor demonstrate immunomodulatory effects on the immune system.
  • Clinical and preclinical studies show reduced cytokine levels like TNF-α and IL-6 due to these psychedelics.
  • Methods included a comprehensive literature search on psychoneuroimmunomodulatory properties over 30 years.
  • Understanding these effects may lead to new treatments for mental health and brain disorders.

Cite This Study

Thuery et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce541https://doi.org/10.1017/neu.2025.10030
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 15-HT2A receptor and psychedelics: a trip through the mechanisms of action and therapeutic potential in mental disorders2026
  2. 2A dual-receptor model of serotonergic psychedelics2024 · 3 citations
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  4. 4Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair2025
  5. 5Neuroinflammation, the gut-brain axis, and psychedelic-assisted psychotherapy: A synthesis of emerging paradigms in psychiatric care2026