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July 25, 2025Open Access

A reciprocal interplay between 5-HT2A and mGlu5 receptors underlies neuroplasticity

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Authors

TOTomas del OlmoMDMathilde DecourcelleMSMartial Sevéno

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Overview

Quantitative phosphoproteomics reveal 5-HT2A and mGlu5 receptor interactions promote neuroplasticity mechanisms in neurons, suggesting new therapeutic avenues.

Key Points

  • The 5-HT2A receptor mediates neuroplasticity induced by psychedelics, influencing synaptic protein networks.
  • Psychedelics enhance phosphorylation of synaptic proteins, linking 5-HT2A receptor activation with mGlu5 receptor signaling.
  • Functional studies show that Shank3 and protein kinase C are crucial for neuroplasticity regulated by these receptors.
  • These findings highlight the reciprocal relationship between 5-HT2A and mGlu5 receptors as vital for understanding neuroplasticity mechanisms.

Cite This Study

Olmo et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce17dhttps://doi.org/10.1101/2025.07.23.666382
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 15-HT2A receptor and psychedelics: a trip through the mechanisms of action and therapeutic potential in mental disorders2026
  2. 2Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors2025 · 12 citations
  3. 3α2-Adrenergic receptor modulates 5-HT2A-mediated behavioral effects of MDMA and psilocybin in mice2026
  4. 4Biased Signaling in Psychedelic Action.2025
  5. 5Pathway-selective signaling of serotonergic psychedelics at 5-HT receptors: Implications for psychoactivity, safety, and therapeutic potential2026 · 4 citations