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This is a Experimental Study study.

September 16, 2025Molecular PsychiatryOpen Access

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

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Psychedelic treatment leads to long-lasting synaptic enhancement in retrosplenial cortex neurons, despite lacking 5-HT2A receptors.
This study shows that presynaptic 5-HT2A receptors on thalamic inputs are necessary for psychedelic-induced plasticity.
Findings could expand therapeutic use of psychedelics for conditions like Alzheimer's disease and PTSD.
The engineered CRISPR-Cas knockout mouse model was utilized to demonstrate these effects in cortical neurons.

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Implication

Experimental findings reveal lasting synaptic changes in cortical circuitry lacking 5-HT2A receptors, suggesting broader psychedelic applications for neuropsychiatric disorders.

Cite This Study

Ekins et al. (2025) studied this question.

synapsesocial.com/papers/68d4506b31b076d99fa57626 https://doi.org/10.1038/s41380-025-03257-w

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Implication

Experimental findings reveal lasting synaptic changes in cortical circuitry lacking 5-HT2A receptors, suggesting broader psychedelic applications for neuropsychiatric disorders.

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

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Discussion

Implication

Cite This Study

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

Key Points

Discussion

Implication

Cite This Study

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