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splice-site SNP responsible for production of the OAS1 p46 isoform correlates with protection from severe COVID-19. This study highlights the importance of endomembrane targeting for the antiviral specificity of OAS1 and suggests that early control of SARS-CoV-2 replication through OAS1 p46 is an important determinant of COVID-19 severity.
Soveg et al. (2021) studied this question. A splice-site SNP responsible for the production of the OAS1 p46 isoform correlates with protection from severe COVID-19 by augmenting antiviral activity through endomembrane targeting.