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November 18, 2003CirculationOpen Access

Severe PV stenosis occurred in 3.4% of patients overall, with rates varying significantly by ablation strategy (15.5%, 20%, 2.9%, 1.4%, and 0%, respectively), and symptoms correlated with involvement of >1 PV with severe narrowing (P=0.01).

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Why the study?

Does the ablation strategy impact the incidence and functional significance of pulmonary vein stenosis in patients undergoing ablation for atrial fibrillation?

Population

608 patients undergoing pulmonary vein isolation for atrial fibrillation

Comparison

Radiofrequency ablation using various strategies vs Comparison among the different ablation strategies

Design

Cohort

Follow-up

3 months

Authors

ESEduardo SaadARAntonio RossilloCSCynthia P. Saad

Discussion

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Overview

Severe PV stenosis rates vary by ablation strategy with symptomatic multi-vein involvement; leaves open optimal technique selection pending randomized data.

Structured PICO

Does the ablation strategy impact the incidence and functional significance of pulmonary vein stenosis in patients undergoing ablation for atrial fibrillation?

P
Population
608 patients undergoing pulmonary vein isolation for atrial fibrillation
I
Intervention
Radiofrequency ablation using various strategies (electroanatomic approach [n=71] or circular mapping [n=537] with distal isolation, ostial isolation based on PV angiography, guided by intracardiac echocardiography, or energy delivery based on visualization of microbubbles)
C
Comparator
Comparison among the different ablation strategies
O
Outcome
Incidence and severity of pulmonary vein stenosis (severe ≥70%, moderate 50-69%, mild <50%) and its functional characterization (symptoms and lung perfusion scans)safety

The incidence of severe pulmonary vein stenosis after atrial fibrillation ablation is declining with the use of better imaging techniques to guide ostial isolation and power titration.

Cite This Study

Saad et al. (2003) studied this question.

synapsesocial.com/papers/6a05223f0012b80f37a1ff61https://doi.org/10.1161/01.cir.0000104569.96907.7f
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