Wearable near-infrared LED photothermal microneedle patch reduces periorbital wrinkles in a randomized pilot clinical trial

Key Points

• This research aimed to evaluate the effectiveness of a wearable photothermal microneedle patch in reducing periorbital wrinkles.
• Conducted a randomized pilot clinical trial with an actively actuated microneedle system.
• Evaluated the impact of dissolving hyaluronic-acid tips on wrinkle reduction in periorbital areas.
• Assessed skin improvements using various photographic and clinical assessments.
• Participants experienced a significant reduction in periorbital wrinkles post-treatment, with 85% reporting visible improvement.
• The treatment showed an increased hydration level in the skin measured by a percentage increase of 30% compared to baseline, p<0.01.
• No serious adverse effects were reported, indicating good tolerance of the microneedle patch.