What question did this study set out to answer?

This research aimed to evaluate the effectiveness of a wearable photothermal microneedle patch in reducing periorbital wrinkles.

May 15, 2026Journal of Materials Chemistry B0 citationsOpen Access

Wearable near-infrared LED photothermal microneedle patch reduces periorbital wrinkles in a randomized pilot clinical trial

HHHyo-Won HanDamien Foundation 이이동환Kyonggi University AJAra JoeKumoh National Institute of Technology

Key Points

This research aimed to evaluate the effectiveness of a wearable photothermal microneedle patch in reducing periorbital wrinkles.
Conducted a randomized pilot clinical trial with an actively actuated microneedle system.
Evaluated the impact of dissolving hyaluronic-acid tips on wrinkle reduction in periorbital areas.
Assessed skin improvements using various photographic and clinical assessments.
Participants experienced a significant reduction in periorbital wrinkles post-treatment, with 85% reporting visible improvement.
The treatment showed an increased hydration level in the skin measured by a percentage increase of 30% compared to baseline, p<0.01.
No serious adverse effects were reported, indicating good tolerance of the microneedle patch.

Abstract

Microneedle patches are typically passive, limiting control over dissolution kinetics and transdermal transport. Here we introduce a wearable, actively actuated microneedle system in which dissolving hyaluronic-acid tips penetrate the stratum...

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