Intravenous insulin administration in dogs produced an early transient pressor response, accompanied by increases in cardiac output and right atrial pressure, suggesting a direct action on the brain.
Cardiovascular responses to intravenous administration of insulin were studied in lightly anesthetized dogs treated with a neuromuscular blocking agent. An early transient pressor response was observed. This abrupt increase in arterial pressure appeared 2–9 min after insulin was given. It was accompanied by increases in cardiac output and right atrial pressure. It occurred in the presence of hyperglycemia and in the absence of hypoglycemia. It was not altered by glucagon but it could be antagonized by ganglionic and adrenergic blocking drugs and by pentobarbital. The response could be produced when insulin was given in the carotid artery in doses that caused no effect when injected in a systemic vein. The experiments suggest that insulin may have a direct action on the brain.
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American Journal of Physiology-Legacy Content
University of Iowa
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Pereda et al. (Thu,) conducted a other in Cardiovascular responses to insulin. Intravenous insulin was evaluated on Cardiovascular responses (arterial pressure, cardiac output, right atrial pressure). Intravenous insulin administration in dogs produced an early transient pressor response, accompanied by increases in cardiac output and right atrial pressure, suggesting a direct action on the brain.