Key result
Intravenous insulin administration in dogs produced an early transient pressor response, accompanied by increases in cardiac output and right atrial pressure, suggesting a direct action on the brain.
Why the study?
Does intravenous administration of insulin affect cardiovascular responses in lightly anesthetized dogs?
Population
lightly anesthetized dogs treated with a neuromuscular blocking agent
Design
Preclinical
Authors
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Insulin may exert central pressor effects in dogs; leaves open translation to human cardiovascular responses.
Does intravenous administration of insulin affect cardiovascular responses in lightly anesthetized dogs?
Insulin administration in dogs causes an acute, transient pressor response and increased cardiac output that appears to be mediated by a direct action on the brain rather than hypoglycemia.
Pereda et al. (1962) studied Cardiovascular responses to insulin. Intravenous insulin was evaluated on Cardiovascular responses (arterial pressure, cardiac output, right atrial pressure). Intravenous insulin administration in dogs produced an early transient pressor response, accompanied by increases in cardiac output and right atrial pressure, suggesting a direct action on the brain.
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