What question did this study set out to answer?

This research evaluates the effects of insulin on blood pressure and sedation in autonomic failure patients.

July 18, 1987BMJOpen Access

Hypotensive and sedative effects of insulin in autonomic failure.

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Why the study?

Does intravenous insulin cause hypotension and sedation in patients with autonomic failure?

Population

9 patients with autonomic failure

Design

Case_series

Follow-up

acute (during test)

Authors

CMC. J. MathiasNational Hospital for Neurology and Neurosurgery DCDiogo CostaHerlev Hospital PFPaul FosbraeyDefence Science and Technology Laboratory

Discussion

Member takes

Implication

Intravenous insulin can cause significant hypotension and sedation without typical hypoglycaemic symptoms in patients with autonomic failure, increasing the risks of insulin stress testing.

Key Points

This research evaluates the effects of insulin on blood pressure and sedation in autonomic failure patients.
Measured blood pressure responses to 0.15 units/kg intravenous insulin in five patient cases.
Observed effects of 50% glucose infusion on blood pressure in four additional patients with autonomic dysfunction.
Used a 10-minute intravenous infusion of 25% glucose to reverse hypoglycemia and assess alertness restoration.
Blood pressure significantly decreased after insulin administration, even before hypoglycemia onset.
All patients exhibited drowsiness without typical hypoglycemic symptoms.
50% glucose infusion caused a temporary blood pressure drop, reversed rapidly with 25% glucose.

Structured PICO

Does intravenous insulin cause hypotension and sedation in patients with autonomic failure?

Population

9 patients with autonomic failure (5 with chronic autonomic failure not receiving drug treatment, and 4 with autonomic dysfunction)

Intervention

Intravenous insulin (0.15 units/kg) or intravenous injection of 25-50 ml of 50% glucose

Outcome

Haemodynamic responses (blood pressure) and symptoms (sedation, neuroglycopenic symptoms)safety

Intravenous insulin can cause significant hypotension and sedation without typical hypoglycaemic symptoms in patients with autonomic failure, increasing the risks of insulin stress testing.

Cite This Study

Mathias et al. (1987) studied this question.

synapsesocial.com/papers/6a212eae570f73dd9ac3cb58 https://doi.org/10.1136/bmj.295.6591.161

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Implication

Intravenous insulin can cause significant hypotension and sedation without typical hypoglycaemic symptoms in patients with autonomic failure, increasing the risks of insulin stress testing.

Hypotensive and sedative effects of insulin in autonomic failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hypotensive and sedative effects of insulin in autonomic failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider