Key result
High-dose insulin infusion in type I diabetics did not significantly change left ventricular ejection fraction compared to low-dose insulin (95% CI for difference -6 to 8%).
Why the study?
Does high-dose insulin infusion alter cardiovascular responses compared to low-dose insulin in hyperglycaemic type I diabetics?
Population
8 hyperglycaemic, resting type I diabetics
Comparison
High-dose insulin infusion for 1 hour vs Low-dose insulin infusion for 1 hour
Design
Other
Follow-up
1 hour
Authors
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High-dose insulin leaves LVEF unchanged in type I diabetes; hypothesis-generating for calf blood volume effects and should not yet change practice.
Does high-dose insulin infusion alter cardiovascular responses compared to low-dose insulin in hyperglycaemic type I diabetics?
High-dose insulin infusion in hyperglycaemic type I diabetics increases calf blood volume without significantly altering left ventricular ejection fraction or systemic hemodynamics compared to low-dose insulin.
Gøtzsche et al. (1991) studied Hyperglycaemic type I diabetes (n=8). High-dose insulin infusion vs. Low-dose insulin infusion (0.005-0.01 IE kg-1 h-1) was evaluated on Difference in left ventricular ejection fraction (95% CI -6 to 8). High-dose insulin infusion in type I diabetics did not significantly change left ventricular ejection fraction compared to low-dose insulin (95% CI for difference -6 to 8%).
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