Key result
Concomitant intravenous infusion of insulin and glucose, producing euglycaemic hyperinsulinaemia, increased left ventricular fractional shortening from 38.2% to 41.0% (p<0.02).
Why the study?
Does euglycaemic hyperinsulinaemia induced by intravenous insulin and glucose infusion increase myocardial contractility in Type 1 diabetic patients?
Population
8 insulin-dependent (Type 1) diabetic patients
Comparison
Continuous intravenous insulin infusion with… vs Continuous intravenous insulin infusion allowing…
Design
RCT, At random, blood glucose was kept constant by concomitant glucose…
Follow-up
180 minutes
Authors
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Suggests acute inotropic benefit from euglycaemic hyperinsulinaemia in T1DM; extends evidence for insulin's direct myocardial actions.
RCT (n=8)
Randomized
Does euglycaemic hyperinsulinaemia induced by intravenous insulin and glucose infusion increase myocardial contractility in Type 1 diabetic patients?
p-value: p=<0.02
Concomitant infusion of insulin and glucose to produce euglycaemic hyperinsulinaemia acutely increases myocardial contractility in Type 1 diabetic patients.
Thuesen et al. (1988) conducted an RCT in Type 1 (insulin-dependent) diabetes (n=8). Intravenous insulin infusion with concomitant glucose vs. Intravenous insulin infusion with falling blood glucose was evaluated on Fractional shortening of the left ventricle (p=<0.02). Concomitant intravenous infusion of insulin and glucose, producing euglycaemic hyperinsulinaemia, increased left ventricular fractional shortening from 38.2% to 41.0% (p<0.02).
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