Why the study?
Does insulin-induced hypoglycemia alter left ventricular systolic and diastolic function differently in intensively treated type 1 diabetic patients compared to healthy nondiabetic subjects?
Population
18 subjects (9 intensively treated patients with type 1 diabetes and 9 healthy nondiabetic subjects)
Comparison
Insulin infusion under hypoglycemic conditions vs Insulin infusion under euglycemic conditions
Design
Other
Follow-up
Acute (during insulin infusion)
Authors
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Blunted cardiac response to hypoglycemia in T1D may signal vulnerability during intensive therapy; hypothesis-generating and requires prospective validation.
Does insulin-induced hypoglycemia alter left ventricular systolic and diastolic function differently in intensively treated type 1 diabetic patients compared to healthy nondiabetic subjects?
Intensively treated type 1 diabetic patients exhibit a blunted and delayed cardiac functional response to insulin-induced hypoglycemia compared to healthy individuals.
Russell et al. (2001) studied this question.
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