Key result
Acute hyperglycemia increases LVEF by ~5% from baseline in patients with T2D.
Why the study?
The effects of acute hyperglycaemia and hypoglycaemia on cardiac function in insulin-treated patients with type 2 diabetes and controls were not well characterized.
Do acute changes in plasma glucose alter left ventricular systolic function in insulin-treated patients with type 2 diabetes and matched controls?
Population
21 insulin-treated T2D patients and 21 matched controls
Comparison
Plasma glucose clamped at fasting, hyperglycaemia, and hypoglycaemia levels
Design
Nonrandomized interventional study
Follow-up
Acute (30-minute steady states)
Authors
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May support glucose standardization before echocardiography in T2D; leaves open effects on clinical decision-making.
Do acute changes in plasma glucose alter left ventricular systolic function in insulin-treated patients with type 2 diabetes and matched controls?
Mean Difference: 4.5 (95% CI 1.1–7.9)
Absolute Event Rate: 4.5% vs 2%
Acute changes in plasma glucose, both hyperglycaemia and hypoglycaemia, increase left ventricular systolic function, suggesting that standardization of plasma glucose may improve reproducibility of echocardiographic assessments in patients with type 2 diabetes.
Andersen et al. (2022) studied Type 2 diabetes (n=42). Plasma glucose clamps (hyperglycaemia and hypoglycaemia) vs. Fasting plasma glucose (baseline) was evaluated on Change in left ventricular ejection fraction from baseline during acute hyperglycaemia (MD 4.5, 95% CI 1.1-7.9). Acute hyperglycaemia increased left ventricular ejection fraction from baseline in patients with type 2 diabetes by 4.5 percentage points (95% CI 1.1-7.9), with no significant interaction between group and glucose level.
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