Key result
Short-term hyperglycemia from insulin discontinuation increases LV systolic function by ~13% in type 2 diabetes.
Why the study?
Does short-term hyperglycemia by insulin discontinuation affect left ventricular contractile function in insulin-treated type 2 diabetic patients with and without heart failure?
Population
18 insulin-treated type 2 diabetic patients, comprising 10 with systolic heart failure and 8 without…
Comparison
Hyperglycemia induced by short-term insulin… vs Normoglycemia for 9-12 hours
Design
RCT, randomized cross-over-designed
Follow-up
9-12 hours
Authors
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Acute hyperglycemia may enhance LV contractility in insulin-treated T2DM; challenges assumptions of uniform harm and extends metabolic modulation research.
RCT (n=18)
Open-label
1:1 allocation
No
Does short-term hyperglycemia by insulin discontinuation affect left ventricular contractile function in insulin-treated type 2 diabetic patients with and without heart failure?
Effect estimate: 12-14% increase
p-value: p=<0.001
Short-term hyperglycemia by insulin discontinuation acutely increases myocardial systolic contractile function in type 2 diabetic patients with and without heart failure.
Nielsen et al. (2013) conducted an RCT in Type 2 diabetes with and without heart failure (n=18). Short-term hyperglycemia (insulin discontinuation) vs. Normoglycemia (plasma glucose 5-7 mM) was evaluated on Maximal global systolic tissue velocity (Vmax) (12-14% increase, p=<0.001). Short-term hyperglycemia induced by insulin discontinuation significantly increased myocardial systolic contractile function, including maximal global systolic tissue velocity, in type 2 diabetic patients with and without heart failure.
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