Effect of tighter glycemic control on cardiac function, exercise capacity, and muscle strength in heart failure patients with type 2 diabetes: a randomized study
Key result
Four months of optimized glycemic control in patients with type 2 diabetes and heart failure preserved muscle strength compared with lenient control (P=0.01), with no effect on LVEF (P=0.18).
Why the study?
Does 4-month optimization of glycemic control improve cardiac function, exercise capacity, muscle strength, and body composition in patients with type 2 diabetes and heart failure?
Population
40 patients with type 2 diabetes and heart failure with left ventricular ejection fraction 35±12% and…
Comparison
4-month optimization of glycemic control vs 4-month non-optimization of glycemic control
Design
RCT, randomized to either 4-month optimization or non-optimization of glycemic…
Follow-up
4 months
Authors
Discussion
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Member takes
Implication
May support optimized control to preserve muscle strength in T2D-HF; extends limited RCT data but leaves hard outcomes open.
Study Design
Type
RCT (n=40)
Randomization
randomized
Structured PICO
Does 4-month optimization of glycemic control improve cardiac function, exercise capacity, muscle strength, and body composition in patients with type 2 diabetes and heart failure?
P
Population
40 patients with type 2 diabetes and heart failure (mean LVEF 35%) randomized to 4-month optimization or non-optimization of glycemic control.
I
Intervention
4-month optimization of glycemic control
C
Comparator
4-month non-optimization (lenient control) of glycemic control
O
Outcome
Changes in left ventricular function (myocardial contractile reserve, LVEF), exercise capacity (oxygen consumption, 6-MWT), muscle strength, and body composition at 4 monthssurrogate
Main Result
p-value: p=0.01
A 4-month optimization of glycemic control in patients with T2D and HF preserved muscle strength and lean body mass without deleterious effects on left ventricular contractile function.
Cite This Study
Nielsen et al. (2016) conducted an RCT in Type 2 diabetes and heart failure (n=40). Optimization of glycemic control vs. Non-optimization of glycemic control (lenient control) was evaluated on Changes in myocardial contractile reserve (LVEF), exercise capacity, and muscle strength (p=0.01). Four months of optimized glycemic control in patients with type 2 diabetes and heart failure preserved muscle strength compared with lenient control (P=0.01), with no effect on LVEF (P=0.18).