July 5, 2019Journal of Clinical MedicineOpen Access

Effects of Different Antidiabetic Medications on Endothelial Glycocalyx, Myocardial Function, and Vascular Function in Type 2 Diabetic Patients: One Year Follow–Up Study

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Why the study?

Poor glycaemic control affects myocardial function, prompting investigation into changes in endothelial function and left ventricular myocardial deformation before and after glycaemic control intensification.

Does intensified glycaemic control improve endothelial function and myocardial deformation in poorly controlled type 2 diabetic patients?

Population

100 poorly-controlled diabetic patients (age: 51 ± 12 years)

Comparison

Before vs 12 months after intensified glycaemic control

Follow-up

12 months

Authors

VLVaia LambadiariPreventive Cardiology GPGeorge PavlidisApple (Israel)FKFoteini KousathanaNational and Kapodistrian University of Athens

Discussion

Member takes

Implication

May support glycaemic intensification for endothelial and myocardial parameters in T2DM; hypothesis-generating pending randomized confirmation.

Structured PICO

Does intensified glycaemic control improve endothelial function and myocardial deformation in poorly controlled type 2 diabetic patients?

Population

100 poorly-controlled type 2 diabetic patients, mean age 51 ± 12 years.

Intervention

Intensified glycaemic control (including incretin-based agents) over 12 months.

Comparator

Baseline (before-and-after comparison) and comparison between patients achieving HbA1c ≤ 7% versus > 7%.

Outcome

Changes in endothelial function (PWV, FMD, PBR) and left ventricular myocardial deformation (GLS, pTw, pTwVel, pUtwVel) at 12 months.surrogate

Intensified glycemic control, particularly with incretin-based agents, improves surrogate markers of arterial stiffness, endothelial glycocalyx, and myocardial deformation in patients with type 2 diabetes.

Cite This Study

Lambadiari et al. (2019) studied this question.

synapsesocial.com/papers/6a7aa923684c0941cf324c6e https://doi.org/10.3390/jcm8070983

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Implication

May support glycaemic intensification for endothelial and myocardial parameters in T2DM; hypothesis-generating pending randomized confirmation.

Effects of Different Antidiabetic Medications on Endothelial Glycocalyx, Myocardial Function, and Vascular Function in Type 2 Diabetic Patients: One Year Follow–Up Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Different Antidiabetic Medications on Endothelial Glycocalyx, Myocardial Function, and Vascular Function in Type 2 Diabetic Patients: One Year Follow–Up Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider