June 14, 2006Clinical Science
Effects of blood pressure lowering and metabolic control on systolic left ventricular function in Type II diabetes mellitus
Why the study?
Does improved metabolic control and blood pressure lowering improve left ventricular systolic long-axis function in hypertensive patients with Type II diabetes mellitus?
Population
48 hypertensive patients with Type II diabetes mellitus participating in the CALM II study
Comparison
Improved glycemic control and blood pressure… vs Patients with increases in HbA1c
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Implication
Improved glycemic control was associated with better LV strain rate in hypertensive type 2 diabetes; hypothesis-generating, needs prospective confirmation before practice change.
Structured PICO
Does improved metabolic control and blood pressure lowering improve left ventricular systolic long-axis function in hypertensive patients with Type II diabetes mellitus?
P
Population
48 hypertensive patients with Type II diabetes mellitus participating in the CALM II (Candesartan and Lisinopril Microalbuminuria II) study
I
Intervention
Improved glycemic control (reduced HbA1c) and blood pressure lowering
C
Comparator
Patients with increases in HbA1c (worsened glycemic control)
O
Outcome
Change in left ventricular systolic long-axis function (peak systolic strain rate) assessed by tissue Doppler echocardiographysurrogate
Improved metabolic control, but not blood pressure reduction, is significantly correlated with improvements in left ventricular systolic long-axis function in hypertensive patients with Type II diabetes.
Cite This Study
Andersen et al. (2006) studied this question.