Key result
Insulin pump therapy correlates with improved HbA1c and corresponding gains in LV strain rate.
Why the study?
The relationship between changes in glycaemic control and left ventricular systolic function in type 1 diabetic patients was unclear.
Does insulin pump therapy improve systolic left ventricular strain rate in type 1 diabetic patients with poor metabolic control?
Observational (n=19)
Does insulin pump therapy improve systolic left ventricular strain rate in type 1 diabetic patients with poor metabolic control?
Effect estimate: r=0.49 (correlation between delta-Strain rate and delta-HbA1c)
p-value: p=<0.01
Improved glycemic control via insulin pump therapy in type 1 diabetes is associated with rapid improvements in subclinical left ventricular systolic function as measured by strain rate.
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May support pump therapy for LV benefits in T1D; hypothesis-generating and leaves open need for RCTs.
Andersen et al. (2007) conducted an observational in Type 1 diabetes mellitus (n=19). Insulin pump therapy vs. Baseline was evaluated on HbA1c and systolic left ventricular strain rate (r=0.49 (correlation between delta-Strain rate and delta-HbA1c), p=<0.01). Insulin pump therapy in type 1 diabetes improved HbA1c and left ventricular strain rate, with changes in glycaemic control correlating with systolic function (r=0.49, p<0.01).
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