Key result
Uncomplicated type 2 diabetes mellitus was associated with lower peak systolic velocity during dobutamine stress compared to controls (11.3 vs 12.5; p<0.001), worsening with coexistent CAD or HTN.
Why the study?
Does uncomplicated type 2 diabetes mellitus cause myocardial dysfunction detectable by dobutamine stress echocardiography, and is it worsened by coexistent cardiovascular diseases?
Cross-Sectional (n=200)
Does uncomplicated type 2 diabetes mellitus cause myocardial dysfunction detectable by dobutamine stress echocardiography, and is it worsened by coexistent cardiovascular diseases?
Absolute Event Rate: 11.3% vs 12.5%
p-value: p=<0.001
Dobutamine stress echocardiography unmasks subclinical myocardial systolic and diastolic dysfunction in uncomplicated type 2 diabetes, which is further exacerbated by coexistent hypertension or coronary artery disease.
No takes yet. Share an insight, caveat, or question.
Supports subclinical dysfunction detection by DSE in uncomplicated T2DM; leaves open prognostic value and intervention thresholds.
Govind et al. (2005) conducted a cross-sectional in Type 2 diabetes mellitus (n=200). Type 2 diabetes mellitus vs. Controls was evaluated on Left ventricular myocardial peak systolic velocity (PSV) during peak stress (p=<0.001). Uncomplicated type 2 diabetes mellitus was associated with lower peak systolic velocity during dobutamine stress compared to controls (11.3 vs 12.5; p<0.001), worsening with coexistent CAD or HTN.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: