
Prevention & Lipids
Blood pressure targets and treatment strategies
Synthesized from 134 evidence-backed clinical questions linked to this topic — 36 supporting the intervention, 42 against the intervention, 10 still contested.
Does antihypertensive drugs vs placebo improve outcomes in Frailty?
Low Certainty+ Favors benefitantihypertensive drugs vs placebo
7 studies (8,985,214 patients) provide low-certainty evidence for benefit of antihypertensive drugs for the outcome in Frailty.
Does antihypertensive vs placebo improve outcomes in Stroke?
Low Certainty− Favors harmantihypertensive vs placebo
8 studies (5,289,215 patients) provide low-certainty evidence against benefit of antihypertensive for the outcome in Stroke.
Does antihypertensives vs placebo improve outcomes in Hypertensive disease?
Insufficient~ Mixed resultsantihypertensives vs placebo · Cardiac Output
452 studies (266,807,266 patients) provide insufficient evidence with mixed findings regarding antihypertensives for Cardiac Output in Hypertensive disease.
Does angiotensin converting enzyme inhibitor vs angiotensin receptor blocker improve outcomes in Hypertensive disease?
Insufficient~ Mixed resultsangiotensin converting enzyme inhibitor vs angiotensin receptor blocker
10 studies (7,152,153 patients) provide insufficient evidence with mixed findings regarding angiotensin converting enzyme inhibitor for the outcome in Hypertensive disease.
Does amlodipine vs chlorthalidone improve outcomes in Hypertensive disease?
Insufficient~ Mixed resultsamlodipine vs chlorthalidone
8 studies (136,774 patients) provide insufficient evidence with mixed findings regarding amlodipine for the outcome in Hypertensive disease.
Does antihypertensive drugs vs diuretic improve outcomes in Hypertensive disease?
Insufficient~ Mixed resultsantihypertensive drugs vs diuretic
6 studies (7,903,740 patients) provide insufficient evidence with mixed findings regarding antihypertensive drugs for the outcome in Hypertensive disease.
Emerging evidence with 100 primary claims
1 question with new evidence. Nothing practice-threatening. 51 new results triaged.
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Awareness of Pediatric Hypertension
JAMA — Pazdral P — May 1976
The distribution and associations of blood pressure in an adolescent population.
Journal of Epidemiology & Community Health — Orchard T — Mar 1982
Effects of perindopril on ambulatory intra-arterial blood pressure, cardiovascular reflexes and forearm blood flow in essential hypertension
Journal of Hypertension — West J — Feb 1989
Effect of angiotensin converting enzyme inhibition on the incidence of restenosis after percutaneous transluminal coronary angioplasty
Catheterization and Cardiovascular Diagnosis — Brozovich F — Aug 1991
Risk factors associated with ST-segment elevation myocardial infarctions among young patients treated in the Mid-West of Ireland: a case series report using secondary data
Irish Journal of Medical Science (1971 -) — Nantumbwe S — May 2025
Inadequate blood pressure control in l'low risk' Mediterranean population
European Heart Journal — Dilaveris P — Dec 1999
Lowering of blood pressure by chronic suppression of central sympathetic outflow: insight from prolonged baroreflex activation
Journal of Applied Physiology — Lohmeier T — Jul 2012
Plasma BNP in patients on maintenance haemodialysis
Journal of Hypertension — Dastoor H — Jan 2005
The LIFE study: the straw that should break the camel's back
European Heart Journal — Messerli F — Mar 2003
Association of hemoglobin with ankle-brachial index in general population
Clinics — Chenglong Z — Jan 2016
Hypertension 1973: Treatment—Why and How
Annals of Internal Medicine — Fröhlich E — May 1973
Renal Function During Long-Term Treatment of Hypertension with Minoxidil
Annals of Internal Medicine — Mitchell H — Nov 1980
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Hypertension management (also known as HTN, high blood pressure, BP management). Blood pressure targets and treatment strategies
As of 2026-08-14, the scientific consensus on Hypertension management is emerging. Emerging evidence with 100 primary claims Based on 100 analyzed claims across Synapse's enriched corpus, the evidence shows.
This evidence brief synthesizes Synapse's enriched cardiology corpus; cite as synapsesocial.com/topics/hypertension-management.
Deterministic synthesis from Synapse's enriched corpus — 57 words. No AI-generated novel content; every figure is sourced from the underlying paper, guideline, or trial record linked on this page.
Explore every Hypertension management paper on Synapse with AI-enriched clinical evidence, PICO analysis, and methodology classification.
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