Impaired Myocardial Functional Reserve in Hypertension and Diabetes Mellitus Without Coronary Artery Disease: Searching for the Possible Link With Congestive Heart Failure in the Myocardial Doppler in Diabetes (MYDID) Study II

128 subjects with apparently normal left ventricular systolic function and without known coronary artery disease (59 with diabetes mellitus, 20 with hypertension, 27 with both diabetes mellitus and hypertension, 22 controls)

Presence of diabetes mellitus, hypertension, or both

Healthy controls

Myocardial functional reserve assessed by standard and dobutamine stress echocardiography using tissue Doppler echocardiography (including LV regional peak systolic velocity, early and late diastolic velocities, strain, and strain rate)surrogate