August 15, 2005Diabetic Medicine
Left ventricular dysfunction in hypertensive patients with Type 2 diabetes mellitus
Why the study?
Does the combination of hypertension and Type 2 diabetes mellitus impair left ventricular longitudinal function in asymptomatic patients with normal ejection fraction?
Population
105 subjects total: 70 hypertensive patients with Type 2 diabetes mellitus, ejection fraction > 0.55…
Comparison
Hypertension and Type 2 diabetes mellitus vs Non-diabetic control subjects
Design
Case-control
Authors
Discussion
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Implication
Impaired longitudinal function may signal early cardiac involvement in asymptomatic hypertensive diabetes; hypothesis-generating for strain imaging utility.
Structured PICO
Does the combination of hypertension and Type 2 diabetes mellitus impair left ventricular longitudinal function in asymptomatic patients with normal ejection fraction?
P
Population
105 subjects total: 70 hypertensive patients with Type 2 diabetes mellitus, ejection fraction > 0.55, fractional shortening > 0.25, and no cardiac symptoms; and 35 non-diabetic control subjects.
I
Intervention
Hypertension and Type 2 diabetes mellitus
C
Comparator
Non-diabetic control subjects
O
Outcome
Left ventricular longitudinal function (tissue Doppler derived myocardial strain rate and peak systolic velocities)surrogate
Asymptomatic hypertensive patients with Type 2 diabetes and normal ejection fraction exhibit impaired left ventricular longitudinal systolic function that correlates with hyperglycemia and left ventricular hypertrophy.
Cite This Study
Andersen et al. (2005) studied this question.