Key result
Type 2 diabetes mellitus was associated with preserved left ventricular systolic function but impaired diastolic relaxation compared to healthy controls, particularly in hypertensive-diabetics.
Why the study?
Does type 2 diabetes mellitus (with or without hypertension) impair left ventricular function in Nigerian patients compared to healthy controls?
Cross-Sectional (n=125)
No
Does type 2 diabetes mellitus (with or without hypertension) impair left ventricular function in Nigerian patients compared to healthy controls?
Type 2 diabetes mellitus is associated with impaired left ventricular diastolic relaxation but preserved systolic function in Nigerian patients, with worse diastolic dysfunction in those with concurrent hypertension.
Answers are grounded in this paper and cite their sources.
May warrant diastolic evaluation in Nigerian diabetics with hypertension; leaves open causality and need for longitudinal outcome studies.
Background. Diabetes mellitus is an established risk factor for cardiovascular events and has been found to be independently associated with abnormal left ventricular function. We therefore decided to embark on this study to assess the left ventricular function in our diabetic patients.Method. The study design was cross-sectional and conducted among patients attending out patient clinic of the Obafemi Awolowo UniversityTeaching Hospitals complex (OAUTHC) Ile Ife, Osun State south western Nigeria. It comprised 75 consecutive patients with type 2 diabetes mellituswith or without hypertension and 50 apparently healthy age- and sex- comparable controls. Using a structured pre-evaluated questionnaire, thedemographic and clinical data were obtained. All subjects had two-dimensional (2D) M-mode, and Doppler echocardiography using Sonoline G60s Ultrasound imaging system with 4.2 MHZ transducer equipped with simultaneous ECG tracing.Results. A total of 125 consecutive subjects were recruited comprising 75 patients with type 2 diabetes mellitus with or without hypertension and50 apparently healthy age-and-sex comparable controls. There were no significant difference in left ventricular ejection fraction and fractionalshortening between the patients and controls. The ratio of early trans-mitral flow to late atrial filling of the left ventricle (E/A ratio), isovolumic leftventricular relaxation time, and left ventricular deceleration time were predominantly prolonged among the study patients compared to the controls.Conclusion. This study showed that left ventricular systolic function was preserved among patients with type 2 diabetes mellitus. The abnormal diastolic function noted was predominantly that of impaired relaxationcompared with controls. This is particularly more in hypertensive-diabetics than normotensive-diabetics.
No takes yet. Share an insight, caveat, or question.
Baba et al. (2013) conducted a cross-sectional in Type 2 diabetes mellitus (n=125). Type 2 diabetes mellitus vs. Healthy controls was evaluated on Left ventricular systolic and diastolic function. Type 2 diabetes mellitus was associated with preserved left ventricular systolic function but impaired diastolic relaxation compared to healthy controls, particularly in hypertensive-diabetics.
Synapse has enriched 10 related papers. Consider them for comparative context: