October 24, 2003Clinical Science
Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated haemoglobin
Why the study?
Do asymptomatic patients with Type II diabetes mellitus have subclinical myocardial dysfunction compared to healthy controls?
Population
70 subjects
Comparison
Type II diabetes mellitus (observational exposure) vs Age- and sex-matched healthy controls
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
May flag subclinical LV dysfunction in asymptomatic diabetes; leaves open whether early detection improves outcomes.
Structured PICO
Do asymptomatic patients with Type II diabetes mellitus have subclinical myocardial dysfunction compared to healthy controls?
P
Population
70 subjects (35 patients with Type II diabetes with no symptoms, signs or history of heart disease, and 35 age- and sex-matched healthy controls)
I
Intervention
Type II diabetes mellitus (observational exposure)
C
Comparator
Age- and sex-matched healthy controls
O
Outcome
Regional ventricular function (longitudinal peak systolic velocity, functional reserve, radial systolic velocity) at rest and during dobutamine stress measured by colour tissue Doppler echocardiographysurrogate
Asymptomatic patients with Type II diabetes exhibit subclinical left ventricular subendocardial dysfunction at rest and during stress, which correlates with HbA1c and LDL-cholesterol levels.
Cite This Study
Vinereanu et al. (2003) studied this question.