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April 20, 2007HeartOpen Access

Abnormal left ventricular longitudinal functional reserve in patients with diabetes mellitus: implication for detecting subclinical myocardial dysfunction using exercise tissue Doppler echocardiography

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Why the study?

Does exercise tissue Doppler echocardiography detect subclinical myocardial dysfunction in patients with type 2 diabetes compared to healthy controls?

Population

106 subjects: 53 patients with type 2 diabetes and 53 age and gender-matched controls. None had…

Comparison

Supine bicycle exercise with tissue Doppler… vs Age and gender-matched controls undergoing the…

Design

Case-control

Authors

JHJong‐Won HaCardiac ImagingHLH.-C. LeeYonsei UniversityEKEun Seok KangYonsei University

Discussion

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Implication

May detect subclinical LV dysfunction in diabetes; hypothesis-generating for prognostic value and management impact.

Structured PICO

Does exercise tissue Doppler echocardiography detect subclinical myocardial dysfunction in patients with type 2 diabetes compared to healthy controls?

P
Population
106 subjects: 53 patients with type 2 diabetes (27 male, mean age 53+/-14 years) and 53 age and gender-matched controls. None had echocardiographic evidence of resting or inducible myocardial ischaemia.
I
Intervention
Supine bicycle exercise (25 W, 3 min increments) with tissue Doppler echocardiography (TDE) assessment
C
Comparator
Age and gender-matched controls undergoing the same exercise protocol
O
Outcome
Mitral annular systolic (S') and early diastolic (E') velocities at rest and during exercisesurrogate

Exercise tissue Doppler echocardiography reveals blunted left ventricular longitudinal functional reserve in patients with type 2 diabetes, identifying early subclinical myocardial dysfunction not apparent at rest.

Cite This Study

Ha et al. (2007) studied this question.

synapsesocial.com/papers/6a7de8ea432a20ae7c150da7https://doi.org/10.1136/hrt.2006.101667

Topics

Cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased left ventricular longitudinal contraction in normotensive and normoalbuminuric patients with Type II diabetes mellitus: a Doppler tissue tracking and strain rate echocardiography study2003 · 106 citations
  2. 2Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants.1993 · 142 citations
  3. 3Mechanism of augmented rate of left ventricular filling during exercise.1992 · 215 citations
  4. 4A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography.1981 · 738 citations
  5. 5C-Peptide Exerts Beneficial Effects on Myocardial Blood Flow and Function in Patients With Type 1 Diabetes2002 · 128 citations