Key result
Intravenous insulin administration in patients with IDDM caused a blunted heart rate increase (2 vs. 6 beats/min; P<0.04) and significant decreases in forearm vascular resistance versus normal subjects.
Why the study?
Does intravenous insulin alter hemodynamic and metabolic responses differently in patients with IDDM compared to normal subjects?
Observational (n=35)
Does intravenous insulin alter hemodynamic and metabolic responses differently in patients with IDDM compared to normal subjects?
Absolute Event Rate: 2% vs 6%
p-value: p=<0.04
Impaired vagal heart rate control and sympathetic nervous dysfunction exaggerate the hemodynamic effects of insulin in patients with IDDM, potentially contributing to insulin-induced hypotension.
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May heighten hypotension risk with insulin in IDDM; hypothesis-generating for autonomic mechanisms and needs prospective confirmation.
Mäkimattila et al. (1998) conducted an observational in Insulin-dependent diabetes mellitus (IDDM) (n=35). i.v. insulin vs. Matched normal subjects was evaluated on Heart rate increase during hyperinsulinemia (beats/min) (p=<0.04). Intravenous insulin administration in patients with IDDM caused a blunted heart rate increase (2 vs. 6 beats/min; P<0.04) and significant decreases in forearm vascular resistance versus normal subjects.
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