Why the study?
Does insulin-induced hypoglycemia elicit different counterregulatory hormonal responses in insulin-dependent diabetics with recurrent severe hypoglycemia compared to healthy volunteers?
Population
22 insulin-dependent diabetics (IDD) with recurrent hypoglycemia and 6 healthy volunteers (total n=28).
Comparison
Constant rate infusion of insulin up to four… vs Healthy volunteers and comparison between IDD…
Design
Cohort
Follow-up
up to four hours
Authors
Loading...
Heightened hypoglycemia risk in long-duration IDD with autonomic neuropathy warrants monitoring; leaves open targeted therapies for counterregulatory restoration.
Does insulin-induced hypoglycemia elicit different counterregulatory hormonal responses in insulin-dependent diabetics with recurrent severe hypoglycemia compared to healthy volunteers?
A subset of insulin-dependent diabetics with recurrent severe hypoglycemia have deficient glucagon and epinephrine counterregulatory responses to hypoglycemia, associated with autonomic neuropathy.
Adamson et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: