Why the study?
Are defects in counterregulatory hormone secretion specific to hypoglycemia in well-controlled IDDM patients?
Population
28 subjects: 9 well-controlled IDDM patients, 9 poorly controlled IDDM patients, and 10 healthy volunteers.
Comparison
3-h hypoglycemic hyperinsulinemic clamp lowering… vs Healthy volunteers and poorly controlled IDDM…
Design
Cross-sectional
Authors
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May indicate generalized counterregulatory impairment in well-controlled IDDM; hypothesis-generating for hypoglycemia risk and glycemic targets.
Are defects in counterregulatory hormone secretion specific to hypoglycemia in well-controlled IDDM patients?
Well-controlled IDDM patients exhibit reduced epinephrine responses to both hypoglycemic and nonhypoglycemic stimuli, while maintaining adequate pituitary functional reserve for ACTH and GH.
Kinsley et al. (1994) studied this question.