Key result
Subcutaneous insulin lowers supine mean blood pressure ~5 mmHg in IDDM patients with autonomic neuropathy.
Why the study?
The hemodynamic effects of therapeutic subcutaneous insulin injection in subjects with insulin-dependent diabetes mellitus (IDDM) with and without autonomic neuropathy were not well characterized.
Does subcutaneous insulin affect hemodynamics and blood pressure in IDDM patients with and without autonomic neuropathy?
Population
17 IDDM subjects with and without autonomic neuropathy and orthostatic hypotension
Comparison
Subcutaneous insulin 0.2 U/kg vs placebo (distilled water)
Design
Randomized controlled trial
Follow-up
120 minutes
Authors
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Subcutaneous insulin may lower BP in IDDM with autonomic neuropathy; leaves open need for monitoring or adjusted regimens in prospective studies.
RCT (n=17)
Does subcutaneous insulin affect hemodynamics and blood pressure in IDDM patients with and without autonomic neuropathy?
p-value: p=<0.05
Therapeutic doses of subcutaneous insulin decrease blood pressure and plasma volume in IDDM patients with autonomic neuropathy, potentially exacerbating orthostatic hypotension.
Porcellati et al. (1993) conducted an RCT in Insulin-Dependent Diabetes Mellitus (IDDM) with or without autonomic neuropathy (n=17). Subcutaneous insulin vs. Placebo (distilled water) was evaluated on Hemodynamic effects including mean blood pressure and plasma volume (p=<0.05). Subcutaneous insulin decreased supine mean blood pressure in IDDM patients with autonomic neuropathy (e.g., from 99 to 94 mmHg; P<0.05), but not in those without autonomic neuropathy.
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