What is the clinical evidence from this study?

Study design: Other. Population: Beta receptor blockade (n=9). Intervention: Insulin vs. Baseline (post-beta blockade). Primary outcome: Haemodynamic variables (LVEDP, LVdP/dtmax, stroke volume, and cardiac output) (p=<0.01).

What question did this study set out to answer?

This research aims to explore how different doses of insulin influence heart function during beta receptor blockade in dogs.

October 1, 1985Clinical Physiology

Haemodynamic effects of low and high doses of insulin during beta receptor blockade in dogs

Q: What are the key findings of this study?

Insulin administration during beta receptor blockade in dogs exerted dose-dependent inotropic and vasodilator effects, significantly improving cardiac performance (P<0.01).

Q: What question did this study set out to answer?

This research aims to explore how different doses of insulin influence heart function during beta receptor blockade in dogs.

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Key result

Insulin administration during beta receptor blockade in dogs exerted dose-dependent inotropic and vasodilator effects, significantly improving cardiac performance (P<0.01).

Why the study?

Does insulin improve haemodynamic performance in dogs with beta receptor blockade?

Population

9 dogs with beta receptor blockade induced by 0.5 mg/kg propranolol

Comparison

Low dose insulin followed 30 minutes later by a… vs Baseline (post-beta blockade state)

Design

Preclinical

Follow-up

Acute (up to 30+ minutes)

Authors

OROlav ReikeråsOslo University Hospital PGPål GunnesSørlandet Hospital Arendal DSDag SørlieUniversity Hospital of North Norway

Discussion

Member takes

Implication

May warrant investigation as adjunctive therapy in beta-blocked states; leaves open translation from canine model to human HF.

Key Points

This research aims to explore how different doses of insulin influence heart function during beta receptor blockade in dogs.
Induced beta receptor blockade using 0.5 mg/kg propranolol in dogs.
Administered low dose (0.5 IU/kg) and high dose (300 IU) of insulin with monitoring of haemodynamic changes.
Maintained glucose and potassium levels during the experiment.
Low dose insulin administration decreases left ventricular end-diastolic pressure (LVEDP) significantly (P<0.01) and increases LVdP/dtmax, stroke volume, and cardiac output (P<0.01).
High dose insulin further enhances cardiac performance and significantly reduces total peripheral resistance.
Overall, insulin shows inotropic and vasodilator effects that are dose-dependent.

Structured PICO

Does insulin improve haemodynamic performance in dogs with beta receptor blockade?

Population

9 dogs with beta receptor blockade induced by 0.5 mg/kg propranolol

Intervention

Low dose insulin (0.5 IU/kg bolus followed by 0.5 IU/kg/h continuous infusion) followed 30 minutes later by a high dose insulin bolus (300 IU), with glucose and potassium to maintain physiological levels

Comparator

Baseline (post-beta blockade state)

Outcome

Haemodynamic parameters including left ventricular end-diastolic pressure (LVEDP), maximum rate of left ventricular pressure rise (LVdP/dtmax), stroke volume, cardiac output, and total peripheral resistancesurrogate

Main Result

p-value: p=<0.01

Insulin exerts dose-dependent inotropic and vasodilator effects that are independent of adrenergic mechanisms in a canine model of beta blockade.

Cite This Study

Reikerås et al. (1985) studied Beta receptor blockade (n=9). Insulin vs. Baseline (post-beta blockade) was evaluated on Haemodynamic variables (LVEDP, LVdP/dtmax, stroke volume, and cardiac output) (p=<0.01). Insulin administration during beta receptor blockade in dogs exerted dose-dependent inotropic and vasodilator effects, significantly improving cardiac performance (P<0.01).

synapsesocial.com/papers/6a08098d113ba5b476ddec43 https://doi.org/10.1111/j.1475-097x.1985.tb00777.x

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Haemodynamic effects of low and high doses of insulin during beta receptor blockade in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Haemodynamic effects of low and high doses of insulin during beta receptor blockade in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider