Key result
Low dose insulin infusions in healthy volunteers significantly increased plasma renin activity (P<0.001), angiotensin II (P<0.001), noradrenaline (P<0.01), and systolic blood pressure (P<0.001).
Why the study?
Does low dose insulin infusion increase renin-angiotensin and sympathetic nervous system activity in healthy volunteers?
Population
Healthy volunteers
Comparison
Sequential 60 min 0.5 and 1.0 mU kg-1 min-1… vs Control infusion simulating clamp conditions
Design
Other
Follow-up
120 minutes (sequential 60 min infusions)
Authors
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Physiological hyperinsulinemia activates RAAS/SNS acutely in health; hypothesis-generating for hypertension mechanisms in insulin resistance.
Does low dose insulin infusion increase renin-angiotensin and sympathetic nervous system activity in healthy volunteers?
Absolute Event Rate: 1.4% vs 1%
p-value: p=<0.001
Acute hyperinsulinaemia within the physiological range increases circulating hormones of the renin-angiotensin and sympathetic nervous systems and raises systolic blood pressure in healthy individuals.
Rooney et al. (1991) studied Healthy volunteers. Insulin infusion vs. Control infusion was evaluated on Plasma renin activity (p=<0.001). Low dose insulin infusions in healthy volunteers significantly increased plasma renin activity (P<0.001), angiotensin II (P<0.001), noradrenaline (P<0.01), and systolic blood pressure (P<0.001).
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