Why the study?
Does the euglycemic glucose clamp procedure itself increase sympathetic nervous system activity compared to saline infusion in healthy young men?
Population
59 healthy young men (n=50 undergoing euglycemic hyperinsulinemic glucose clamp, n=9 controls)
Comparison
Euglycemic hyperinsulinemic glucose clamp vs Saline infusion instead of glucose and insulin
Design
Other
Follow-up
Short term (during the clamp)
Authors
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Clamp procedures alone raise norepinephrine; leaves open hyperinsulinemia's independent sympathetic effects and requires controls in future studies.
Does the euglycemic glucose clamp procedure itself increase sympathetic nervous system activity compared to saline infusion in healthy young men?
The increase in plasma norepinephrine observed during an euglycemic glucose clamp is likely due to the procedure itself rather than hyperinsulinemia, highlighting the need for control groups in such studies.
Moan et al. (1995) studied this question.
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