What is the clinical evidence from this study?

Study design: Other. Population: Borderline hypertension (n=25). Intervention: Isoglycemic hyperinsulinemic glucose clamp vs. Saline solution. Primary outcome: Blood pressure and sympathetic responses (norepinephrine and epinephrine) to mental stress (p=0.8 for norepinephrine, 0.7 for epinephrine).

What does this research mean for the field?

Acute hyperinsulinemia during an isoglycemic glucose clamp does not significantly alter cardiovascular or sympathetic responses, including norepinephrine and epinephrine levels, to mental stress in borderline hypertensive men. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the impact of acute hyperinsulinemia during an isoglycemic glucose clamp on cardiovascular and sympathetic nervous system responses to mental stress.

January 1, 2000American Journal of HypertensionOpen Access

Effects of hyperinsulinemia on sympathetic responses to mental stress

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Key result

Acute hyperinsulinemia during an isoglycemic glucose clamp did not significantly alter norepinephrine (P=0.8) or epinephrine (P=0.7) responses to mental stress in borderline hypertensive men.

Why the study?

Does acute hyperinsulinemia alter cardiovascular or sympathetic responses to mental stress in borderline hypertensive young men?

Population

25 borderline hypertensive but otherwise healthy 21-year-old men

Comparison

Isoglycemic hyperinsulinemic glucose clamp for… vs Saline solution infusion with mental arithmetic…

Design

Other

Follow-up

120 minutes

Authors

AHAud HøieggenOslo University Hospital

Discussion

Member takes

Implication

Acute hyperinsulinemia does not modify sympathetic stress responses; leaves open chronic insulin effects on reactivity in hypertension.

Key Points

To evaluate the impact of acute hyperinsulinemia during an isoglycemic glucose clamp on cardiovascular and sympathetic nervous system responses to mental stress.
Eighteen borderline hypertensive, otherwise healthy 21-year-old men underwent a 5-minute mental arithmetic stress test before (MST-1) and at the end of a 120-minute isoglycemic hyperinsulinemic glucose clamp (MST-2).
A parallel control group (n = 7) underwent the same protocol with saline solution infusion to account for potential time-dependent effects.
Plasma insulin increased from 119 ± 10 pmol/L to 752 ± 65 pmol/L, but neither insulin nor saline infusions altered the significant mental-stress-induced increases in blood pressure and heart rate.
Plasma norepinephrine increases during mental stress were 461 ± 165 pmol/L at baseline versus 372 ± 112 pmol/L during hyperinsulinemia (P = .8).
Plasma epinephrine increases during mental stress were 218 ± 76 pmol/L at baseline versus 187 ± 60 pmol/L during hyperinsulinemia (P = .7).

Structured PICO

Does acute hyperinsulinemia alter cardiovascular or sympathetic responses to mental stress in borderline hypertensive young men?

Population

25 borderline hypertensive but otherwise healthy 21-year-old men (n=18 in insulin group, n=7 in saline control group)

Intervention

Isoglycemic hyperinsulinemic glucose clamp for 120 min with mental arithmetic stress testing

Comparator

Saline solution infusion with mental arithmetic stress testing

Outcome

Blood pressure, heart rate, and plasma catecholamine (norepinephrine and epinephrine) responses to mental stresssurrogate

Main Result

p-value: p=0.8 for norepinephrine, 0.7 for epinephrine

Acute hyperinsulinemia does not appear to interfere with cardiovascular or sympathetic responses to mental stress in borderline hypertensive young men.

Cite This Study

Aud Høieggen (2000) studied Borderline hypertension (n=25). Isoglycemic hyperinsulinemic glucose clamp vs. Saline solution was evaluated on Blood pressure and sympathetic responses (norepinephrine and epinephrine) to mental stress (p=0.8 for norepinephrine, 0.7 for epinephrine). Acute hyperinsulinemia during an isoglycemic glucose clamp did not significantly alter norepinephrine (P=0.8) or epinephrine (P=0.7) responses to mental stress in borderline hypertensive men.

synapsesocial.com/papers/6a1c99a71e0790f17da177cb https://doi.org/10.1016/s0895-7061(99)00146-6

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Effects of hyperinsulinemia on sympathetic responses to mental stress

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Effects of hyperinsulinemia on sympathetic responses to mental stress

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

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