Key result
Intrabrachial insulin infusion had a gradual vasodilator effect but did not significantly alter forearm blood flow increase during mental stress compared to placebo (81% vs 92%; P=NS).
Why the study?
Does intrabrachial insulin infusion alter vascular responses to mental stress and norepinephrine in normotensive men?
RCT (n=9)
Double-blind
randomized
Does intrabrachial insulin infusion alter vascular responses to mental stress and norepinephrine in normotensive men?
Absolute Event Rate: 81% vs 92%
p-value: p=NS
Local hyperinsulinemia induces vasodilation and maintains increased forearm blood flow during mental stress and norepinephrine infusion in healthy men.
Authors
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Insulin does not modify mental stress vascular responses in healthy men; extends local vasodilatory insights but leaves clinical relevance open.
Sverker Jern (1994) conducted an RCT in Healthy volunteers (n=9). Insulin vs. Placebo was evaluated on Forearm blood flow increase during mental stress (p=NS). Intrabrachial insulin infusion had a gradual vasodilator effect but did not significantly alter forearm blood flow increase during mental stress compared to placebo (81% vs 92%; P=NS).
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