Key result
Regional forearm physiological hyperinsulinemia increased forearm muscle blood flow by a median of 26% after 180 minutes (P<0.05), but did not alter skin blood flow or peripheral venous tone.
Why the study?
Does physiological hyperinsulinemia affect peripheral blood flow and noradrenaline responsiveness in skeletal muscle, skin, and peripheral veins?
Population
n=22 subjects undergoing evaluation of regional/local physiological hyperinsulinemia
Comparison
Insulin infusion with noradrenaline infusion vs Baseline measurements prior to insulin infusion
Design
Other
Follow-up
180 minutes
Authors
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Insulin selectively augments muscle perfusion without venous or skin effects; leaves open its role in insulin resistance and metabolic vascular regulation.
Does physiological hyperinsulinemia affect peripheral blood flow and noradrenaline responsiveness in skeletal muscle, skin, and peripheral veins?
p-value: p=< 0.05
Physiological hyperinsulinemia has a slow-onset vasodilator effect on skeletal muscle resistance vessels but does not affect skin vasculature, peripheral veins, or noradrenergic responsiveness.
C. de Haan (1997) studied this question. Insulin vs. Baseline was evaluated on Forearm (muscle) blood flow (FBF) (p=< 0.05). Regional forearm physiological hyperinsulinemia increased forearm muscle blood flow by a median of 26% after 180 minutes (P<0.05), but did not alter skin blood flow or peripheral venous tone.
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