July 1, 1993HypertensionOpen Access

Intra-arterial infusion of insulin attenuates vasoreactivity in human forearm.

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Why the study?

Does intra-arterial infusion of insulin attenuate vascular reactivity to phenylephrine or angiotensin II in young, healthy volunteers?

Population

10 young, healthy volunteers

Comparison

Intra-arterial infusion of insulin… vs Infusion of phenylephrine and angiotensin II…

Design

Other

Authors

KSK. SakaiSocial Insurance Saitama Chuo Hospital TITakahiro ImaizumiNagoya University HMHiroaki MasakiWaseda University

Discussion

Member takes

Implication

Does not warrant practice change in hypertension; leaves open relevance of insulin's vascular effects beyond healthy volunteers.

Structured PICO

Does intra-arterial infusion of insulin attenuate vascular reactivity to phenylephrine or angiotensin II in young, healthy volunteers?

Population

10 young, healthy volunteers

Intervention

Intra-arterial infusion of insulin (0.15 mU/kg per minute) simultaneously with phenylephrine (0.2, 0.8, and 2.4 micrograms/min) and angiotensin II (5, 10, and 20 ng/min)

Comparator

Infusion of phenylephrine and angiotensin II before insulin infusion

Outcome

Vascular reactivity (forearm vascular resistance and blood flow) to phenylephrine and angiotensin IIsurrogate

Hyperinsulinemia attenuates vascular reactivity to vasoconstrictors in the forearm resistance vessels of healthy humans.

Cite This Study

Sakai et al. (1993) studied this question.

synapsesocial.com/papers/6a7d970f0631e052c4b86d9d https://doi.org/10.1161/01.hyp.22.1.67

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Ask AI

Bookmark

Intra-arterial infusion of insulin attenuates vasoreactivity in human forearm.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intra-arterial infusion of insulin attenuates vasoreactivity in human forearm.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider